In the dome, the frescoes depict the figures of great prophets, while the small domes feature angels, and the pendentives display the Evangelists. The apse showcases the Communion of the Apostles and the Adoration of the Lamb, while the altar contains several Old Testament scenes and individual saints. The choir areas depict holy warriors and compositions of Christ's parables. On the columns, there is the Vision of Peter of Alexandria, individual saints, and archangels. The western wall is adorned with the Dormition of the Virgin and a portrait of Despot Stefan holding a model of the church. On the other walls of the church, remnants of medallions with busts of saints, individual figures, and fragments of scenes from the cycles of Great Feasts, Miracles, and the Earthly Life of Christ can be found.

The figures are well-proportioned and elegant, with a confident drawing style and exceptional modeling. Among the anonymous masters who frescoed the church of the Manasija Monastery, there were undoubtedly several outstanding icon painters who, in terms of artistic merit, can be compared to the greatest painters of the 15th century.

With its powerful fortifications, towers, church architecture, extraordinary frescoes, and old monastic quarters, Manasija ranks among the most well-preserved medieval monastic complexes.